- Obesity and Metabolism
- Genetic and Environmental Factors Contributing to Visceral Adiposity in Asian Populations
-
Rachel Williams, Muthu Periasamy
-
Endocrinol Metab. 2020;35(4):681-695. Published online December 23, 2020
-
DOI: https://doi.org/10.3803/EnM.2020.772
-
-
8,913
View
-
204
Download
-
27
Web of Science
-
29
Crossref
-
Abstract
PDFPubReader ePub
- Obesity-associated metabolic illnesses are increasing at an alarming rate in Asian countries. A common feature observed in the Asian population is a higher incidence of abdominal obesity—the “skinny-fat” Asian syndrome. In this review, we critically evaluate the relative roles of genetics and environmental factors on fat distribution in Asian populations. While there is an upward trend in obesity among most Asian countries, it appears particularly conspicuous in Malaysia. We propose a novel theory, the Malaysian gene-environment multiplier hypothesis, which explains how ancestral variations in feast-and-famine cycles contribute to inherited genetic predispositions that, when acted on by modern-day stressors—most notably, urbanization, westernization, lifestyle changes, dietary transitions, cultural pressures, and stress—contribute to increased visceral adiposity in Asian populations. At present, the major determinants contributing to visceral adiposity in Asians are far from conclusive, but we seek to highlight critical areas for further research.
-
Citations
Citations to this article as recorded by
- Differences in the levels of inflammatory markers between metabolically healthy obese and other obesity phenotypes in adults: A systematic review and meta-analysis
Zhouli Su, Ljupcho Efremov, Rafael Mikolajczyk Nutrition, Metabolism and Cardiovascular Diseases.2024; 34(2): 251. CrossRef - Relationship between metabolically healthy obesity and coronary artery calcification
Yoo-Bin Seo, Sung-Goo Kang, Sang-Wook Song Obesity Research & Clinical Practice.2024; 18(1): 28. CrossRef - Visceral Adipose Tissue: The Hidden Culprit for Type 2 Diabetes
Sneha Dhokte, Krzysztof Czaja Nutrients.2024; 16(7): 1015. CrossRef - Diagnostics of the body composition of an elderly person to assess the prognosis of his health
S. V. Bulgakova, D. P. Kurmaev, E. V. Treneva Experimental and Clinical Gastroenterology.2024; (2): 89. CrossRef - Epicardial, peripancreatic and other “orthotopic” excessive fat deposition in south Asians and Europeans: Are differences clinically relevant?
Niki Katsiki, Manfredi Rizzo, Dimitri P. Mikhailidis Journal of Diabetes and its Complications.2023; 37(4): 108419. CrossRef - External validation of Prediabetes Risk Test in Indian population for screening prediabetes
Radhika Aditya Jadhav, G. Arun Maiya, Shashikiran Umakanth, K.N. Shivashankara Medical Journal Armed Forces India.2023;[Epub] CrossRef - Evaluation of Nutritional Characteristics Reveals Similar Prevalence of Malnutrition in Patients with Ulcerative Colitis and Crohn’s Disease
Arshdeep Singh, Vandana Midha, Ramit Mahajan, Shruti Verma, Chandan Kakkar, Jasmine Grover, Dharmatma Singh, Ramandeep Kaur, Abhishek Masih, Namita Bansal, Catherine Wall, Ajit Sood Digestive Diseases and Sciences.2023; 68(2): 580. CrossRef - A comparison study of prevalence, awareness, treatment and control rates of hypertension and associated factors among adults in China and the United States based on national survey data
Xiaomin Sun, Xinguang Chen, Zumin Shi, Alice Fang Yan, Zhongying Li, Shiqi Chen, Bingtong Zhao, Wen Peng, Xi Li, Mei Zhang, Limin Wang, Jing Wu, Youfa Wang Global Health Journal.2023; 7(1): 24. CrossRef - Clinical characteristics and efficacy of pioglitazone in a Japanese patient with familial partial lipodystrophy due to peroxisome proliferator-activated receptor γ gene mutation
Toru Iizaka, Eriko Kodama, Kentaro Mikura, Tatsuya Iida, Hideyuki Imai, Mai Hashizume, Yasuyoshi Kigawa, Chiho Sugisawa, Rie Tadokoro, Kei Endo, Fumiko Otsuka, Masayo Isoda, Ken Ebihara, Shun Ishibashi, Shoichiro Nagasaka Endocrine Journal.2023; 70(1): 69. CrossRef - Sex- and age-specific association between outdoor light at night and obesity in Chinese adults: A national cross-sectional study of 98,658 participants from 162 study sites
Xiaoyun Zhang, Ruizhi Zheng, Zhuojun Xin, Zhiyun Zhao, Mian Li, Tiange Wang, Min Xu, Jieli Lu, Shuangyuan Wang, Hong Lin, Weiqing Wang, Guang Ning, Yufang Bi, Yuhong Chen, Yu Xu Frontiers in Endocrinology.2023;[Epub] CrossRef - Obesity and Abdominal Obesity in Indian Population: Findings from a Nationally Representative Study of 698,286 Participants
Rajat Das Gupta, Nowrin Tamanna, Nazeeba Siddika, Shams Shabab Haider, Ehsanul Hoque Apu, Mohammad Rifat Haider Epidemiologia.2023; 4(2): 163. CrossRef - Factors Associated with Normal-Weight Abdominal Obesity Phenotype in a Representative Sample of the Peruvian Population: A 4-Year Pooled Cross-Sectional Study
Jamee Guerra Valencia, Lorena Saavedra-Garcia, Víctor Juan Vera-Ponce, Rubén Espinoza-Rojas, Noel C. Barengo Journal of Clinical Medicine.2023; 12(10): 3482. CrossRef - Gene–Diet Interactions on Metabolic Disease-Related Outcomes in Southeast Asian Populations: A Systematic Review
Padmini Sekar, Eduard Flores Ventura, Anto Cordelia T. A. Dhanapal, Eddy Seong Guan Cheah, Annaletchumy Loganathan, Phoon Lee Quen, Mahenderan Appukutty, Nurpudji Astuti Taslim, Hardinsyah Hardinsyah, Mohd Fairulnizal Md Noh, Julie A Lovegrove, Ian Givens Nutrients.2023; 15(13): 2948. CrossRef - Assessing the usefulness of a newly proposed metabolic score for visceral fat in predicting future diabetes: results from the NAGALA cohort study
Ruijuan Yang, Maobin Kuang, Jiajun Qiu, Changhui Yu, Guotai Sheng, Yang Zou Frontiers in Endocrinology.2023;[Epub] CrossRef - A maladaptive parental effect: offspring survival decreases with maternal over-condition in an amphibian
Emily A Harmon, Tianxiu Li, Patrick W Kelly, Catherine Chen, David W Pfennig, Karin S Pfennig Biological Journal of the Linnean Society.2023; 140(4): 578. CrossRef - Epicardial fat and Stage B heart failure among overweight/obese and normal weight individuals with diabetes mellitus
Yukari Kobayashi, Tomoko Nishi, Jeffery W. Christle, Nicholas Cauwenberghs, Tatiana Kuznetsova, Latha Palaniappan, Francois Haddad The International Journal of Cardiovascular Imaging.2023; 39(12): 2451. CrossRef - Clinical outcomes of obese and nonobese patients with atrial fibrillation according to associated metabolic abnormalities: A report from the COOL‐AF registry
Rungroj Krittayaphong, Thanita Boonyapiphat, Arjbordin Winijkul, Gregory Y. H. Lip Journal of Diabetes.2023;[Epub] CrossRef - Association between individual and environmental factors with body mass index for age z-score in female adolescents living in North-West of Iran
Bahareh Seyyedin, Nasrin Omidvar, Bahar Bakhshi, Farid Zayeri, Arezoo Rezazadeh Nutrition & Food Science
.2022; 52(4): 595. CrossRef - Obesity epidemic through the prism of evolutionary processes
O. T. Kim, O. M. Drapkina Cardiovascular Therapy and Prevention.2022; 21(1): 3109. CrossRef - East Asian perspectives in metabolic and bariatric surgery
Tae Jung Oh, Hyuk‐Joon Lee, Young Min Cho Journal of Diabetes Investigation.2022; 13(5): 756. CrossRef - Measurement of visceral fat for early prediction of prediabetes—Cross-sectional study from Southern India
Radhika A. Jadhav, G. Arun Maiya, K.N. Shivashankara, Shashikiran Umakanth Journal of Taibah University Medical Sciences.2022; 17(6): 983. CrossRef - Interaction of polygenic variants specific for abdominal obesity risk with energy metabolism in large Korean cohorts
Sunmin Park Nutrition Bulletin.2022; 47(3): 307. CrossRef - Interconnection between cardiovascular, renal and metabolic disorders: A narrative review with a focus on Japan
Takashi Kadowaki, Hiroshi Maegawa, Hirotaka Watada, Daisuke Yabe, Koichi Node, Toyoaki Murohara, Jun Wada Diabetes, Obesity and Metabolism.2022; 24(12): 2283. CrossRef - Relationship between the Duration of Urban Nature and a Lower Waist-Hip Ratio
Pongsakorn Suppakittpaisarn, Nadchawan Charoenlertthanakit, Ekachai Yaipimol, Vipavee Surinseng, Chulalux Wanitchayapaisit, Gunwoo Kim International Journal of Environmental Research and Public Health.2022; 19(18): 11606. CrossRef - Relationship of Functional Constipation and Growth Status: A Systematic Review and Meta-Analysis
Glen Lazarus, Michelle Clarissa Junaidi, Hanifah Oswari Journal of Pediatric Gastroenterology & Nutrition.2022; 75(6): 702. CrossRef - Implementation of Nutrigenetics and Nutrigenomics Research and Training Activities for Developing Precision Nutrition Strategies in Malaysia
Anto Cordelia T. A. Dhanapal, Ramatu Wuni, Eduard F. Ventura, Teh Kuan Chiet, Eddy S. G. Cheah, Annaletchumy Loganathan, Phoon Lee Quen, Mahenderan Appukutty, Mohd F. M. Noh, Ian Givens, Karani Santhanakrishnan Vimaleswaran Nutrients.2022; 14(23): 5108. CrossRef - Sex-specific association of exposure to bedroom light at night with general and abdominal adiposity in young adults
Yu-xiang Xu, An-hui Zhang, Yang Yu, Yu-hui Wan, Fang-biao Tao, Ying Sun Ecotoxicology and Environmental Safety.2021; 223: 112561. CrossRef - Expert opinion on the preoperative medical optimization of adults with diabetes undergoing metabolic surgery
Saptarshi Bhattacharya, Sanjay Kalra, Nitin Kapoor, Rajiv Singla, Deep Dutta, Sameer Aggarwal, Deepak Khandelwal, Vineet Surana, Atul Dhingra, Viny Kantroo, Sachin Chittawar, Nilakshi Deka, Vivek Bindal, Puja Dutta World Journal of Diabetes.2021; 12(10): 1587. CrossRef - Unravelling Polycystic Ovary Syndrome and Its Comorbidities
Kyung-Wook Kim Journal of Obesity & Metabolic Syndrome.2021; 30(3): 209. CrossRef
|